Mohsen Fathzadeh  

MSc of Human Genetic

Biographical Information

Surname: FATHZADEH

First name: MOHSEN

Date of birth: 09.10.1973 / 1352/07/17

Place of birth: Shiraz

Nationality: Iranian

Male/Married/Number of Children: 1

Academic History

• MSc of Human Genetic (1999-2002)

Department of Biology, Shaheed Beheshti University, Tehran, Iran.

• BSc of Animal Biology (1992-1997)

Department of Biology, Tehran University, Tehran, Iran.

• Member of research team (2007- present)

Since a cardiovascular research center was established at Shiraz University of Medical sciences (SUMS)(http://www.sums.ac.ir/),

• Director (2002-2007)

Human Genetics Research Group, Iranian Academic Center for Education, Culture and Research (ACECR), Fars Branch, Shiraz, Iran. http://research.acecr.ac.ir/

• Member of research team (2001-2002)

Research Center for Gastroenterology and liver Disease, Shaheed, Beheshti University of Medical Science, Taleghani Hospital, Tehran, Iran. http://www.rcgld.org/en_main/index.php

• Genetic counselor (2000-2001)

Children medical center Hospital, Hematology ward, Tehran, Iran.

Courses

1.      Course of “Medical Journalism”. Part 1, June 10-12, 2008. Part 2, August 5-7, 2008. Shiraz, Iran.

2.      Workshop of “Endnote” software for bibliographies. May 8, 2008. Shiraz, Iran

3.      Workshop of “Systematic review and meta-analysis”. March 12-13, 2008. Shiraz, Iran

4.      Workshop of "Taking Research Grants from different international sources". March 11, 2008. Shiraz, Iran

Previous Research Experience:

1. Cardiovascular Research Center, SUMS, Shiraz, Iran.

I am a full-time member of the center. During 8 moths ago , I have written a proposal titled "Screening of high risk populations for premature coronary atherosclerosis (pCAD)in Fars province: family history and ethnicity". This project has currently been approve d by a cost 810,000,000 Rials (~ 81,000 $). By this study we will recruit 500 families of multiple cases of pCAD, establish DNA Bank finally perform linkage mapping in order to find responsible gene (in collaboration with Dr Arya Mani, Yale University).

Two more study:

A.    SNPs in PCSK9 gene in two ethnic population of pCAD.

B.     SNPs of a structural gene in Bicuspid aortic valve; this project has gone under a collaboration between our center and Cardiovascular laboratory at Yale University by representativeness of Dr Arya Mani.

2. Hematology Research center, SUMS, Shiraz, Iran.

I have started new research activity during two months ago. Up to now I have experienced sequencing with ABI PRISM^TM 310 Genetic Analyzer (one capillary), to sequence beta-globin gene, and "ARMS" to screen known point mutation of the gene in order to evaluate PND of thalassemia fetus.

3. Iranian Cardiovascular Research Journal (http://www.icrj.ir/).

A member of Editorial Board of the journal (ISSN 1735-885X        e-ISSN 1735-8868).

4. Iranian Academic Center for Education, Culture & Research (ACECR), Shiraz.

Two research proposal:

1. Study of pedigree and family history in mentally retarded (MR) children caring at the Welfare and rehabilitation centers.
2. Cytogenetic study of sever mentally retarded children and moderately retarded children with mothers by history of recurrent abortion.

Publications

1. Fathzadeh M, Babaie Bigi MA, Bazrgar M, Yavarian M, et al. Genetic counseling in southern Iran: Consanguinity and reason for referral. Journal of Genetic Counseling 2008 Jun 13. 17:472_479.
2. Bazrgar M, Karimi M, Fathzadeh M, et al. Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts. Mol Biol Rep. 2007 Jun 27; [Epub ahead of print]
3. Bazrgar M, Karimi M, Peiravian F, Fathzadeh M. Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major. Haematologica. 2007 Feb;92(2):256-7.
4. Fathzadeh M, Seyedna Y, Khazali H, et al. Epidemiological study of T4, T3 and TSH mean concentrations in the four Iranian populations, Shiraz, Mashhad, Rasht and Ilam. Iranian Journal of Public Health, 2005; 34 (1): 74-79.
5. Fathzadeh M, Hadi N, et al. Genetic and non-genetic disorders among progenies of consanguineous marriages: a survey of genetic consultants' pedigrees in Shiraz 2000-2003. Journal of Medical research, Shiraz [Persian] 2005; 3(4):95-100 [Persian].
6. Senemar S, Droudchi M, Pezeshki AM, Ghderi A, Fathzadeh M, et al. Frequency of 844ins68bp allele of CBS gene in normal population of Iran. Journal of Biology, Iran 2005; 20 (2): 225-32 [Persian].
7. Bazrgar M, Peyravian F, Karimi M, Fathzadeh M. Left ventricular dysfunction in Beta thalassemia major: A correlation study between hematological parameters and iron chelation with echocardiographic findings. 10th international congress of Thalassemia and haemoglobinopathies & 12th international TIF conference for thalassemia patients and parents. 7-10 January 2006 Dubai UAE.
8. Fathzadeh M, Senemar S, Babaie MA, et al Impact of family history and consanguinity in severity of mental retardation in children. Iranian Journal o f Pediatrics, 2007: 17 (Suppl 3); 2 [Persian].
9. Bazrgar M, Karimi M, Peiravian F, Fathzadeh M, et al.. Apolipoprotein E4 allele and the risk of left ventricular dysfunction in thalassemia major. ICRJ 2007, 1(1): 13-19.
10. Fathzadeh M, Babaie MA, et al. Genetic Counseling in Southern Iran: Need for Population Based Genetic Counseling. The First ‎International Congress on Hearth Genomics and Biotechnology. Nov 24- 26- Tehran, Iran. Poster 1-3-‎‎10158.‎
11. Senemar S, Droudchi M, Pezeshki AM, Bazrgar M, Fathzadeh M, et al. Frequency of 844INS68, Cystathionine ‎ ‎- Synthase polymorphism as an Anthropological Marker to ‎Diversity of Southern Iran Population from Other Populations. Archives of Iranian Medicine 2007, ‎‎10(4) (supp l. 1), S193.
12. Bazrgar M, Karimi M, Peiravian F, Fathzadeh M, Aminian B. Apolipoprotein E gene Polymorphism and left ventricular function in thalassemia major from south of ‎Iran. Iranian Heart Journal 2006, supp 1.5: 57.‎

Research Interests

Since its appearance at 1960's, molecular genetics has had huge impact on progression of all branches of biomedical professions. Development of high-throughput instruments for research and diagnostic purposes of genetic diseases at DNA and chromosomal level has opened a new arena of health care services. It is not far-fetched that 'personalized medicine' based on genomic characterization of each individual will be integrated into health policy of countries. With completion of Human Genome Project, the launching Human Variome Project (Cotton RG, 2007) and probable extension of HapMap project (hapmap.org) to other populations it is essential to retrieve all variations compiled in human genome both in the heath and ill conditions.

I am very interested in mapping genes for familial form of monogenic and common complex disorders by linkage analysis and operating DNA-chip Microarray systems. Also, I think study of Single Nucleotide Polymorphisms (SNPs) and their role by functional genomic is the most prominent challenge of post-genomic era.

I can describe my key interest in medical genetic as:

1. identification and characterization of genes of diseases
2. linkage and association analysis of SNPs variants in common complex disorders
3. population genetics; genomic diversity and diseases
4. Genetic counseling; genomics and public heath.

Some deficient in technical equipment in our country, has been a barrier to perform some idea of research. The above keys of interest prompt me to apply to national research programs. All courses such as bioinformatics, functional genomic, gene mapping and functional analysis are important. This valuable position motivates me to expand my basic knowledge of genetics and my experience into applications for better identification of genetic disorders.

Honors, Scholarships, Prices and Awards

• First rank of "Human branch" for oral presentation of Mental retardation in children:  Mutual effect of consanguinity and family history, in the 10^th Iranian Genetics Congress, which was organized by Iranian Genetics Society on 21-23 May, 2008 at Razi Conference hall, Tehran, Iran (http://www.cigs.ir/).

• A grant costs ~81,000 $ has currently been approved by Official Board of Technology of Fars Province for a research proposal which I have prepared, titled 'screening of high risk populations in Fars province for premature coronary atherosclerosis based on family history and ethnicity.'

At this fairly extensive project we will recruit families of interest by focusing in those who have family history of premature MI and coronary disease. In addition of saving DNA of patients, we consider ethnicity, pedigree data in standard soft wares, and recruiting presymptomatic relatives who are at risk of developing the disease in near future. Finally we apply for linkage mapping in candidate families with certain inheritance pattern of the disease.

• The second grade of Iranian Ministry of Science, Research & Technology for admission in MSc. level of human genetics at Shaeed Beheshti University. This position was available just at two national universities. Up to 7 students were accepted in the course among a few hundreds had been examined.

Date     06.21.2008                                         Signature  Mohsen Fathzadeh